West Ham's mixed start to the season under new boss Julen Lopetegui continued at Fulham last weekend, with Danny Ings' 95th-minute equaliser clinching a late point.
The Hammers are yet to pick up a point in their two home league matches, having fallen to defeats against Aston Villa and Manchester City.
Chelsea picked up their second league victory of the season at Bournemouth last time out, with substitute Christopher Nkunku's late finish enough to seal all three points.
The Blues have not won any of their last three trips to the London Stadium, losing two of those meetings.
A high-scoring draw would appear the likeliest outcome here.